By Elizabeth A. Stewart MD
You might have referred to as in in poor health this present day. Your again and legs harm. Your stomach is bloated and greater than a bit uncomfortable. you're having your interval, and the bleeding is so heavy you cannot even take into consideration leaving the home. you may have uterine fibroids.One in each 4 girls see their lives plagued by uterine fibroids, which could reason heavy bleeding, belly bloating, discomfort, and infertility. the indications will be mildly demanding or existence changing in severity. until eventually lately, hysterectomy was once the single method to medication fibroids, and every yr greater than 200,000 hysterectomies are played within the usa to regard those noncancerous growths. yet hysterectomy isn't the easiest resolution. The approach may be devastating for ladies who have been making plans to get pregnant, and it's a major surgical procedure for someone. during this finished and compassionate advisor, Dr. Elizabeth A. Stewart is helping ladies comprehend the therapies now available.An the world over famous professional on fibroids, Dr. Stewart describes all of the on hand clinical and surgical remedies in addition to substitute and complementary treatments. as well as hysterectomy, she explains uterine artery embolization (UAE), noninvasive targeted ultrasound (FUS), and cutting edge hormone remedies. easy diagrams and images illustrate the situation -- and its remedy. Dr. Stewart encourages ladies with fibroids to profit up to they could prior to deciding upon a remedy plan. offering the main trustworthy and updated details in this quite common and tough illness, she is helping ladies comprehend uterine fibroids and make the absolute best offerings approximately their care. (September 2008)
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Additional info for Uterine Fibroids: The Complete Guide (A Johns Hopkins Press Health Book)
Steroid hormones can easily pass through the cell membrane and carry out their action in the nucleus of the cell, the control center where the DNA directs the action (fig. 2). The key to understanding the action of these hormones is that they bind with proteins called receptors; it is the hormone-receptor complex that brings about the changes by binding to DNA. Hormones and receptors fit together like locks and keys. The analogy is apt. You can have an office-specific key as well as a pass key that fits all the locks in the office; similarly, different hormone-receptor combinations can give different results.
Steroid hormones such as estrogen, progesterone, and testosterone work in the nucleus of the cell. They easily pass through cell membranes and bind to receptors in the cells. Different hormones and different types of receptors can bind to DNA in slightly different ways to turn on specific proteins. In this illustration both estrogen and a selective estrogen receptor modulator (SERM, such as tamoxifen) go easily from the bloodstream (in the upper left) into the cell and on into the nucleus. Although in this diagram it is estrogen that is interacting with both the alpha and beta estrogen receptors to produce two different RNAs and thus two different proteins, the SERM could also interact with each and have a different effect on the cell.
Originally, we simplistically assumed that women with uterine fibroids had an enlarged endometrial cavity and therefore this larger surface caused increased bleeding at the time of menstruation. While increased surface area may play a role, we want to explore all the possible causes. In this chapter we will examine a number of theories that may influence fibroid formation, growth, and symptoms. Genetic Causes of Fibroids One major theory is that some women are genetically predisposed to form fibroids.
Uterine Fibroids: The Complete Guide (A Johns Hopkins Press Health Book) by Elizabeth A. Stewart MD