By Rakesh N. Veedu
Aptamers, frequently termed as ‘chemical antibodies,’ are an rising category of artificial ligands for effective target-specific molecular popularity. the target of this ebook is to spotlight fresh advances and strength of aptamers in numerous disorder stipulations. . This booklet specializes in the functions of aptamers in distinctive nanotherapy, detection, and in molecular imaging in a variety of illness stipulations equivalent to melanoma, neurological illnesses and infectious diseases.
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Extra resources for Aptamers: Tools for Nanotherapy and Molecular Imaging
1993). Enzymatic recognition of the base pair between isocytidine and isoguanosine, Biochemistry, 32, pp. 10489–10496. April 8, 2016 12:8 PSP Book - 9in x 6in 22 History of Aptamer Development 37. Sismour, A. , Park, J. , Lutz, M. , Boyer, P. , Hughes, S. , and Benner, S. A. (2004). , 32, pp. 728–735. 38. , Brody, E. , Dalby, A. , Eaton, B. , Keeney, T. , Koch, T. , Nelson, S. , Ostroﬀ, R. , Resnicow, D. , Vaught, J. , Walker, J. , Wilcox, S. , Wolk, S. , and Zichi, D. (2010). Aptamer-based multiplexed proteomic technology for biomarker discovery, PLoS One, 5, p.
Chem. , 43, pp. 631–641. 45. , and Furste, J. P. (2012). Properties of an LNA-modiﬁed ricin RNA aptamer, Biochem. Biophys. Res. , 419, pp. 60–65. 01-Veedu-Rakesh-c01 April 8, 2016 12:8 PSP Book - 9in x 6in 01-Veedu-Rakesh-c01 References 23 46. Schmidt, K. , Stephens, A. , and Erdmann, V. A. (2004). , 32, pp. 5757–5765. 47. Tucker, W. , Shum, K. , and Tanner, J. A. (2012). G-quadruplex DNA aptamers and their ligands: structure, function and application, Curr. Pharmaceut. Design, 18, pp. 2014–2026.
ISM showed that schema search is also critical for aptamer improvement. It is noteworthy that ISM can target any function of aptamers, including speciﬁcity and inhibitory activity for improvement with in vitro or even in vivo evaluation, whereas conventional SELEX approaches are limited to aﬃnitybased selection. Aptamer development using GAs was also demonstrated using high-throughput DNA microarrays [65, 73]. The CLADE approach that employed a GA process starting with an array of random sequences explored a sequence–ﬁtness landscape of aptamers and developed aptamers with aﬃnity for ﬂuorescent  and biotinylated proteins [74, 75].
Aptamers: Tools for Nanotherapy and Molecular Imaging by Rakesh N. Veedu