By Carl Eisdorfer PhD MD
New york 1982 Springer. 8vo, 436pp., index, unique gilt published hardcover. VG, tiny chip on entrance, no DJ.
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Additional resources for Annual Review of Gerontology and Geriatrics, Volume 3, 1982: Clinical, Behavioral and Social Issues
This resistance to tolerance induction was shown, by cell transfer studies, to be an intrinsic property of the peripheral B-cell population of older mice. The detailed mechanism for the age-related decrease in the ease of B-cell tolerance induction is not known. , 1972; DeKruyff and Siskind, 1980; Szewczuk and Siskind, 1977). The reduced affinity of the B-cell population of aged mice may thus contribute to the lack of susceptibility to tolerance induction. A defect in the capping of the surface immunoglobulin of B cells from aged rats following treatment with anti-immunoglobulin antibody has been reported (Woda and Feldman, 1979).
The major enzymatic step is the oxidation of ethanol to acetaldehyde by liver alcohol dehydrogenase (ADH). Smith et al. (1973) described multiple bands of ADH on starch gel electrophorcsis, attributed to three ADH gene loci in the liver. 8. This difference now has been correlated with electrophoretic variation at the ADH-2 locus. , 1975). Harada et al. (1980) have confirmed and extended these findings on ADH and shown, in addition, that 52 percent of Japanese have an unusual pattern of aldehyde dehydrogenase isozymes, with lower activity in metabolizing the highly potent acetaldehyde, which may well mediate certain intoxicating and toxic effects of ethanol.
Animal Studies Animal data must be interpreted with some caution. One cannot assume that other species metabolize drugs with the same pathway as does man; many exceptions have been reported (Omenn, 1976). Nevertheless, strain differences and species differences in the metabolism of specific drugs may provide useful models for the enzymatic steps involved and for correlation of metabolic degradation rates with therapeutic and adverse physiological or behavioral effects. Animal strains with markedly different longevity or different patterns of age-related diseases (Storer, 1966; Omenn, 1980) may be useful in seeking models for pharmacogenetic and pharmacokinetic aspects of aging.
Annual Review of Gerontology and Geriatrics, Volume 3, 1982: Clinical, Behavioral and Social Issues by Carl Eisdorfer PhD MD