Download Aging. Oxidative Stress and Dietary Antioxidants by Victor R. Preedy PDF

By Victor R. Preedy

ISBN-10: 0124059333

ISBN-13: 9780124059337

Aging: Oxidative pressure and nutritional Antioxidants bridges the trans-disciplinary divide and covers in one quantity the technology of oxidative pressure in getting older and the doubtless healing use of typical antioxidants within the vitamin or foodstuff matrix. The tactics in the technological know-how of oxidative rigidity are defined in live performance with different procedures, akin to apoptosis, telephone signaling, and receptor mediated responses. This strategy acknowledges that ailments are usually multifactorial, and oxidative pressure is a unmarried section of this.

Gerontologists, geriatricians, nutritionists, and dieticians are separated via divergent abilities disciplines that have to be bridged on the way to strengthen preventative in addition to remedy concepts. whereas gerontologists and geriatricians might learn the underlying strategies of getting older, they're much less prone to be acquainted with the technology of meals and dietetics. nevertheless, nutritionists and dietitians are much less conversant with the targeted scientific historical past and technology of gerontology. This e-book addresses this hole and brings each one of those disciplines to endure at the methods inherent within the oxidative pressure of getting older.

  • Nutritionists can follow info concerning mitochondrial oxidative rigidity in a single ailment to diet-related techniques in one other unrelated ailment
  • Dietitians can prescribe new meals or diets containing anti-oxidants for stipulations immune to traditional pharmacological remedies
  • Dietitians, after studying concerning the easy biology of oxidative rigidity, might be in a position to recommend new remedies to their multidisciplinary teams
  • Nutritionists and dietitians will achieve an knowing of mobilephone signaling and manage to recommend new preventative or healing thoughts with anti-oxidant wealthy foods

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Circulation 2010;122:2170– 82. 958033. Kawashima T, Inuzuka Y, Okuda J, Kato T, Niizuma S, Tamaki Y, Iwanaga Y, Kawamoto A, Narazaki M, Matsuda T, et al. Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice. J Mol Cell Cardiol 2011;51:1026–36. 013. Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, et al. SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 2007;21:2644–58.

00004-4 39 © 2014 Elsevier Inc. All rights reserved. 40 4. AGING, OXIDATIVE STRESS AND THE LIVER EVIDENCE FOR AGE-ASSOCIATED MORPHOLOGIC, STRUCTURAL AND FUNCTIONAL CHANGES IN THE LIVER Aging of the liver manifests as both structural and functional alterations and is evident in humans and rodents. Early ultrasound studies suggest that liver from healthy individuals undergoes a significant 30% reduction in volume with increasing age (reviewed in ref. 6). 7 Consistent with impaired age-related changes in liver structure, hepatic blood circulation is significantly reduced 30–50% in rodents and human subjects and this correlates with increasing age (reviewed in ref.

Razzaque MS. The role of Klotho in energy metabolism. Nat Rev Endocrinol 2012;8:579–87. 75. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390:45–51. Kurosu H, Yamamoto M, Clark JD, et al. Suppression of aging in mice by the hormone Klotho. Science 2005;309:1829–33. Pedersen L, Pedersen SM, Brasen CL, Rasmussen LM. Soluble serum Klotho levels in healthy subjects. Comparison of two different immunoassays.

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Aging. Oxidative Stress and Dietary Antioxidants by Victor R. Preedy

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