By Anthony E. Redington, Alyn H. Morice
A complete evaluate of the medical and medical features of acute and protracted cough, this reference makes a speciality of contemporary advancements in our knowing of the molecular biology of putative cough receptors, the neural mechanisms excited by the afferent and efferent limbs, the relevant processing of the cough reflex, and peptides and different ingredients which may mediate or modulate the cough reflex. With chapters written via said gurus within the box, this instruction manual covers present and power healing brokers, numerous methodologies to degree cough reflex sensitivity, and scientific techniques for the evaluation of continual cough in adults and kids.
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Extra resources for Acute and Chronic Cough
Notably, pulmonary C-fibers in dogs may be unresponsive to histamine, while bronchial C-fibers are activated by histamine. Whether similar physiological distinctions between bronchial and pulmonary afferent C-fibers can be defined in other species is not known. In guinea pigs, histamine appears to have no effect on bronchopulmonary C-fibers. Undem and colleagues (56,57) have recently described C-fiber subtypes innervating the intrapulmonary airways and lungs of mice and guinea pigs. In guinea pigs, C-fiber subtypes may be distinguished based on their ganglionic origin and sites of termination in the airways.
Afferent nerves innervating other viscera as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature also likely play a less essential but important accessory role in regulating cough. In this chapter the classes of vagal afferent nerves innervating the airways and their role in regulating the cough reflex will be defined. Classification of Airway Afferent Nerve Subtypes Airway afferent nerve subtypes are abundant in the airway mucosa and in the airway wall and can be differentiated based on their physicochemical sensitivity, adaptation to sustained lung inflation, neurochemistry, origin, myelination, conduction velocity, and sites of termination in the airways (Fig.
Nature 2002; 416:52–58. 127. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A. A TRP channel that senses cold stimuli and menthol. Cell 2002; 108:705–715. 24 Hwang 128. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 2003; 33:129–137. 129. Ong AC, Ward CJ, Butler RJ, Biddolph S, Bowker C, Torra R, Pei Y, Harris PC.
Acute and Chronic Cough by Anthony E. Redington, Alyn H. Morice